Tookad-vtp for Recurrent Prostate Cancer after Failure of Ebrt; Escalating Light Doses Trachtenberg
نویسندگان
چکیده
1 Surgical Oncology, 2 Division of BioPhysics and BioImaging, 4 Department of Medical Imaging, 6 Department of Pathology, Ontario Cancer Institute/Princess Margaret Hospital/University Health Network, 3 Department of Physics, Ryerson University, and 5 Department of Medical Imaging, Mt. Sinai Hospital, University of Toronto, Toronto, Departments of Urology, 8 McGill University, Montreal, QC, 9 University of Western Ontario, London, Canada, and 7 Department of Plant Sciences, Weizmann Institute of Science, Rehovot, Israel Accepted for publication 8 February 2008
منابع مشابه
Vascular targeted photodynamic therapy with palladium-bacteriopheophorbide photosensitizer for recurrent prostate cancer following definitive radiation therapy: assessment of safety and treatment response.
PURPOSE Tookad is a novel intravascular photosensitizer. When activated by 763 nm light, it destroys tumors by damaging their blood supply. It then clears rapidly from the circulatory system. To our knowledge we report the first application of Tookad vascular targeted photodynamic therapy in humans. We assessed the safety, pharmacokinetics and preliminary treatment response as a salvage procedu...
متن کاملTreatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer.
With the development of new photosensitizers that are activated by light at longer wavelengths, interstitial photodynamic therapy (PDT) is emerging as a feasible alternative for the treatment of larger volumes of tissue. Described here is the application of PDT treatment planning software developed by our group to ensure complete coverage of larger, geometrically complex target volumes such as ...
متن کاملDetermination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localised prostate cancer using WST11-vascular-targeted photodynamic (VTP) therapy.
OBJECTIVE To determine the optimal drug and light dose for prostate ablation using WST11 (TOOKAD Soluble) for vascular-targeted photodynamic (VTP) therapy in men with low-risk prostate cancer. PATIENTS AND METHODS In all, 42 men with low-risk prostate cancer were enrolled in the study but two who underwent anaesthesia for the procedure did not receive the drug or light dose. Thus, 40 men rece...
متن کاملCapacitive Hyperthermia as an Alternative to Brachytherapy in Treatment of Human Prostate Cancer Cell
Introduction: The aim of this study was the evaluation of induced DNA damages of human prostate cancer cells, DU-145, treated with a combination of radiofrequency capacitive hyperthermia (HT) and teletherapy (EBRT) compared to a combination of teletherapy with high dose rate brachytherapy (BR). Materials and Methods: DU-145 cells were cultured as spheroids ...
متن کاملPermanent Occlusion of Feeding Arteries and Draining Veins in Solid Mouse Tumors by Vascular Targeted Photodynamic Therapy (VTP) with Tookad
BACKGROUND Antiangiogenic and anti-vascular therapies present intriguing alternatives to cancer therapy. However, despite promising preclinical results and significant delays in tumor progression, none have demonstrated long-term curative features to date. Here, we show that a single treatment session of Tookad-based vascular targeted photodynamic therapy (VTP) promotes permanent arrest of tumo...
متن کامل